Timing, risk, and reality: early venous thromboembolism chemoprophylaxis in patients with TBI requiring operative intervention
Abstract
Venous thromboembolism (VTE) prevention has become a central focus of contemporary trauma care.1–3 There has been a shift toward early chemoprophylaxis; however, reservations persist regarding the optimal timing in patients with traumatic brain injury (TBI) given concerns for intracranial hemorrhage progression, which can be devastating. Understanding the optimal timing of chemoprophylaxis in TBI is particularly challenging as TBI is a highly heterogeneous disease process. Patients requiring neurosurgical intervention represent a subset of patients at a particularly high bleeding risk.
Fields of Study & Subjects
Venous Thromboembolism Diagnosis and Management
Traumatic Brain Injury and Neurovascular Disturbances
Trauma
Hemostasis
Coagulopathy
Resuscitation
Publication details
- Journal / source
- Trauma Surgery & Acute Care Open
- Volume
- 11
- Issue
- 1
- Pages
- e002265–e002265
- Publication date
- 1 January 2026
- Language
- EN