Design of 1V Low-Power CMOS TIA with High Performance for Integrated Biomedical Applications

This paper presents a high-performance transimpedance amplifier (TIA) designed as an analog front-end circuit tailored for low-voltage, low-power optoelectronic sensor systems used in wearable, portable and implantable biomedical devices. With the increasing integration of sensors across diverse sectors, including industry, biomedicine, agriculture, environmental monitoring and workplace safety. There is a rising demand for compact sensor systems featuring minimal electronic components that can be seamlessly fabricated using standard CMOS technology. In biomedical applications in particular, it is crucial to develop sensor systems that are both small in size and consume very little power. Such features ensure that the devices remain noninvasive and comfortable for patients, enabling continuous health monitoring, support for personalized treatments and integration with prosthetics for improved autonomous living. The proposed TIA architecture is implemented at the transistor level using TSMC 0.13[Formula: see text] [Formula: see text]m standard CMOS technology. It is optimized to handle nanoampere-range pulsed input currents, such as those produced by silicon photodiodes in optical sensing systems. Operating at a 1[Formula: see text]V single supply, the circuit consumes a maximum of approximately 15[Formula: see text] [Formula: see text]W of power. It offers a gain up to 116[Formula: see text]dB[Formula: see text], a bandwidth extending up to around 440[Formula: see text]kHz, and exhibits low-noise performance with a minimum noise floor of roughly 2.1[Formula: see text] [Formula: see text]. The full circuit design is comprehensively detailed, and its performance has been thoroughly evaluated through post-layout simulations.