Simultaneous Brain Iron and α-Synuclein Detection in Patients with Synucleinopathies via Quantitative Susceptibility Mapping MRI

Radiology 2026 Open access

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Authors: Zhenghao Li, Zeyun Zhu, Shiran Lv, Xiaojun Guan, Yuyao Zhang, Cong Liu, D. Li, Hongjiang Wei
DOI: 10.1148/radiol.251189
Cited by: 3
References: 32

Abstract

< .05). Subvoxel QSM enabled synucleinopathy differentiation (areas under receiver operating characteristic curve: PD vs HC, 0.87 [95% CI: 0.82, 0.92]; MSA vs HC, 0.94 [95% CI: 0.90, 0.98]; and PD vs MSA, 0.96 [95% CI: 0.93, 0.98]). Conclusion Subvoxel QSM enabled simultaneous measurement of α-Syn aggregation and iron deposition in patients with synucleinopathies, effectively distinguishing PD from MSA and both from HCs. © The Author(s) 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments Transcranial Magnetic Stimulation Studies Neurological disorders and treatments

Publication details

Journal / source
Radiology
Publisher
Radiological Society of North America (RSNA)
Volume
318
Issue
2
Pages
e251189–e251189
Publication date
1 February 2026
Language
EN