Noninvasive Differentiation of Indolent from Aggressive Renal Neoplasms with MR Fingerprinting Combined with Diffusion/Perfusion MRI

Radiology 2026 Open access

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Authors: Sree Harsha Tirumani, Christina J. MacAskill, Yilun Sun, Dheeman Futela, Holly Lynn Harper, Adam Christopher Calaway, Bernd Kuehn, Ke Cheng Liu, Lee Evan Ponsky, Mark Alan Griswold, Chris A. Flask, Yong Chen
DOI: 10.1148/radiol.251404
Cited by: 0
References: 32

Abstract

> .05). The area under the receiver operating characteristic curve (AUC) values of T1, T2, ADC, and RBF alone for between-group differentiation were 0.39, 0.83, 0.38, and 0.62, respectively. Multivariable analysis revealed that MRF-derived T1 and T2 provided complementary information in tumor type differentiation, achieving an AUC of 0.89 in this initial exploratory analysis. Conclusion Rapid multiparametric quantitative imaging with kidney MRF improved the ability to assess the grade and aggressiveness of renal neoplasms in 15 seconds per imaging section and without injectable MRI contrast material. © The Author(s) 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.

Fields of Study & Subjects

MRI in cancer diagnosis Advanced MRI Techniques and Applications Renal cell carcinoma treatment

Publication details

Journal / source
Radiology
Volume
318
Issue
3
Pages
e251404–e251404
Publication date
1 March 2026
Language
EN