Midbrain Energy Homeostasis Biomarker for Differential Diagnosis of Early-Stage Parkinson Disease: A 1 H and 31 P MRI Study

Radiology 2026

View at publisher
Authors: Qiurong Yu, Youmin Zhang, Pei Huang, Yan Li, Peng Liu, Zhijia Jin, Xinhui Wang, Baoyi Zhang, Jinyuan Weng, Peng Wu, Ewart Mark Haacke, Evita Wiegers
+6 more Jannie P. Wijnen, Dennis W. J. Klomp, Sven Haller, S. Chen, F. H. Yan, Naying He
DOI: 10.1148/radiol.251533
Cited by: 2
References: 32

Abstract

Disrupted midbrain energy homeostasis, derived from phosphorus 31 ( 31 P) MR spectroscopy, effectively differentiated early-stage Parkinson disease from its mimics, outperforming conventional hydrogen 1 MRI markers for iron and neuromelanin, establishing 31 P MR spectroscopy as a promising diagnostic tool.

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments Advanced MRI Techniques and Applications Neurological disorders and treatments

Publication details

Journal / source
Radiology
Publisher
Radiological Society of North America (RSNA)
Volume
319
Issue
1
Pages
e251533–e251533
Publication date
1 April 2026
Language
EN