Radiologic Pattern of Fibrosis in Combined Pulmonary Fibrosis and Emphysema: Impact on Disease Trajectories and Prognostic Outcomes

Radiology 2026 Open access

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Authors: Min Seon Kim, Jooae Choe, Hye Jeon Hwang, Ho Cheol Kim, Eun Jin Chae, Joon Beom Seo
DOI: 10.1148/radiol.251686
Cited by: 1
References: 29

Abstract

= .64). Greater baseline fibrosis extent (adjusted hazard ratio [HR]: 1.04; 95% CI: 1.02, 1.06), lung cancer (adjusted HR: 3.90; 95% CI: 2.55, 5.96), and acute exacerbation (adjusted HR: 4.31; 95% CI: 2.68, 6.94) were associated with worse survival. Conclusion In patients with CPFE, radiologic fibrosis patterns were associated with the rate of fibrosis progression, whereas survival was primarily determined by baseline fibrosis extent and adverse clinical events, including the development of lung cancer. © The Author(s) 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.

Fields of Study & Subjects

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Lung Cancer Treatments and Mutations Chronic Obstructive Pulmonary Disease (COPD) Research

Publication details

Journal / source
Radiology
Publisher
Radiological Society of North America (RSNA)
Volume
318
Issue
2
Pages
e251686–e251686
Publication date
1 February 2026
Language
EN