Simple and Versatile Electrochemical Synthesis of Highly Substituted 2,1-Benzisoxazoles

ECS Meeting Abstracts 2026 Open access

Read full text
Authors: Marola S. Lenhard, Johannes G. Winter, Alexander Sandvoß, María de Jesús Gálvez‐Vázquez, Dieter Schollmeyer, Siegfried R. Waldvogel
DOI: 10.1149/ma2026-01552684mtgabs
Cited by: 0

Abstract

A sustainable, general and scalable electrochemical protocol for the direct access to 3-(acylamidoalkyl)-2,1-benzisoxazoles by cathodic reduction of widely accessible nitro arenes is established. The method is characterised by a simple undivided set-up under constant current conditions, inexpensive and reusable carbon-based electrodes, and environmentally benign reaction conditions. The versatility of the developed protocol is demonstrated on 38 highly diverse examples with up to 81% yield. A 50-fold scale-up electrolysis highlights its relevance for preparative applications.

Fields of Study & Subjects

Inorganic and Organometallic Chemistry Chemical Synthesis and Reactions Organic Chemistry Cycloaddition Reactions

Publication details

Journal / source
ECS Meeting Abstracts
Publisher
The Electrochemical Society
Volume
MA2026-01
Issue
55
Pages
2684–2684
Publication date
7 July 2026
Language
EN