Role of Na + /H + exchanger 3 in acidification and morphological remodeling of tubulovesicles in gastric parietal cells

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Takuto Fujii, Hayato Shimizu, Pattama Wiriyasermkul, Shushi Nagamori, Takahiro Shimizu, H Sakai
DOI: 10.1152/ajpcell.00071.2026
Cited by: 1
References: 54

Abstract

exchanger 3 (NHE3) as a key regulator of the transition of gastric parietal cells from the acid-secreting state to the resting state. Using purified gastric tubulovesicles and primary cultured rat parietal cells, we demonstrate for the first time that NHE3 prevents excessive tubulovesicular acidification and promotes membrane remodeling. These findings provide new insight into the homeostasis of parietal cells in the regulation of gastric acid secretion.

Fields of Study & Subjects

Ion Transport and Channel Regulation Drug Transport and Resistance Mechanisms Neuroscience of respiration and sleep

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
C1605–C1615
Publication date
11 April 2026
Language
EN