Ribosome dynamics during skeletal muscle repair and regeneration in mice and humans

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Minying Cui, Sebastian Edman, Baptiste Jude, Paulo R. Jannig, Oscar Horwath, Emily Shorter, Pieter J Koopmans, Toby L. Chambers, Ronald G. Jones, Abraham Nilsson, Johanna T. Lanner, Thomas Sejersen
+4 more Eva Pontén, Kevin A. Murach, Jörg Schilcher, Ferdinand von Walden
DOI: 10.1152/ajpcell.00184.2026
Cited by: 1
References: 34

Abstract

Our findings establish ribosome biogenesis and ribosome remodeling as core components of the skeletal muscle regenerative program conserved across species. The rapid, MYC-driven induction of translational capacity, coupled with a transient switch in ribosomal protein composition, increases ribosome heterogeneity during skeletal muscle regeneration.

Fields of Study & Subjects

Muscle Physiology and Disorders RNA modifications and cancer RNA and protein synthesis mechanisms

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
331
Issue
1
Pages
C30–C40
Publication date
1 May 2026
Language
EN