Loss of ovarian hormones modulates sex-specific metabolic adaptations to volumetric muscle loss

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Angela S. Bruzina, William T. Juckett, Faezeh Mozafari, Carlee G. Freeman, Jarrod A. Call, Sarah M. Greising
DOI: 10.1152/ajpcell.00251.2026
Cited by: 1
References: 82

Abstract

This study combined ovariectomy and volumetric muscle loss injury model to investigate if ovarian hormones play a protective role in females during the sequelae of traumatic skeletal muscle injury. The loss of ovarian hormones induces whole body and cellular metabolic inflexibility and worsened functional recovery, identifying ovarian hormones as key regulators of VML-induced metabolic pathophysiology.

Fields of Study & Subjects

Lipid metabolism and biosynthesis Muscle Physiology and Disorders Adipose Tissue and Metabolism

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
331
Issue
1
Pages
C117–C136
Publication date
5 June 2026
Language
EN