Sexual dimorphic pattern of renal transporters and channels in spontaneously hypertensive rats

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Lingyun Xiong, Ariel M. Finch, Donna L. Ralph, Babatunde Shuaib Anidu, Louise Christine Evans, Alicia Ann McDonough
DOI: 10.1152/ajpcell.00256.2026
Cited by: 1
References: 56

Abstract

Hypertension comes in many varieties, instigated by unrelated factors including genetic, hormonal, stress, and environmental factors. Hypertension provides a natriuretic stimulus to match sodium output to intake, which controls circulating volume. This study compares two distinct hypertension models and two sexes: SHR (slowly developing genetic HTN) and AngII infusion hypertension. Results define which sodium transporters' activation drives the hypertension versus which transporters' activity is depressed by the hypertension to maintain fluid and electrolyte balance.

Fields of Study & Subjects

Renin-Angiotensin System Studies Nitric Oxide and Endothelin Effects Sodium Intake and Health

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
331
Issue
2
Pages
C293–C300
Publication date
15 June 2026
Language
EN