Placental small extracellular vesicles as modulators of bisphenol A-induced oxidative stress and mitochondrial activation in human astrocytoma cells (U-373 MG)

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Serena Nencini, Alice Pifferi, Sofia Passaponti, Filiberto Maria Severi, Caterina Bocchi, Silvia Canaletti, Roberta Romagnoli, Laura Cresti, Leonardo Ermini, Francesca Ietta
DOI: 10.1152/ajpcell.00312.2025
Cited by: 1
References: 47

Abstract

The study demonstrates that BPA induces oxidative stress and mitochondrial dysfunction in human astrocytes. It introduces a novel role of sEVs in counteracting these effects by reducing ROS, restoring mitochondrial activity, and upregulating antioxidant enzymes. Notably, sEVs from BPA-exposed placental explants were more efficiently incorporated into astrocytes, suggesting an adaptive protective mechanism. These findings highlight a potential fetal neuroprotective role of placental sEVs against environmental stressors.

Fields of Study & Subjects

Effects and risks of endocrine disrupting chemicals Pregnancy and preeclampsia studies Extracellular vesicles in disease

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
C794–C806
Publication date
21 February 2026
Language
EN