Effects of proANP 31–67 in a preclinical model of uninephrectomy and cardiac ischemia/reperfusion injury: cardiac remodeling and tissue biochemical profiling

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Gustavo Jose Justo Silva, Sara Stefani, Reza Parvan, Michael Frisk, Xin Shen, Martina Alunni Cardinali, Mari E. Strand, Karoline Bjarnesdatter Rypdal, Mathis Korseberg Stokke, Håvard Attramadal, Ida G. Lunde, Jan Magnus Aronsen
+4 more Kåre‐Olav Stensløkken, William E. Louch, Paola Sassi, Alessandro Cataliotti
DOI: 10.1152/ajpcell.00339.2025
Cited by: 2
References: 56

Abstract

In a model of reduced nephron mass combined with cardiac ischemia/reperfusion injury, proANP 31–67 prevented adverse cardiac remodeling independent of blood pressure. Vibrational spectroscopy identified coordinated biochemical alterations in cardiac and renal tissues not detected by conventional assays, providing molecular-level insight into cardiorenal remodeling.

Fields of Study & Subjects

Cardiac Fibrosis and Remodeling Tissue Engineering and Regenerative Medicine Acute Kidney Injury Research

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
5
Pages
C1246–C1259
Publication date
14 March 2026
Language
EN