Lyophilized mesenchymal stem cell-derived extracellular vesicles improve outcomes in acute liver failure models

American Journal of Physiology-Cell Physiology 2026

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Authors: Fumiya Suzuki, Hiroaki Haga, Tatsutoshi Inuzuka, Kyoko Tomita Hoshikawa, Tomohiro Katsumi, Keita Maki, Fumi Uchiyama, Yoshiyuki Ueno
DOI: 10.1152/ajpcell.00361.2025
Cited by: 1
References: 51

Abstract

This study establishes lyophilization with 5% sucrose as an effective preservation method for mesenchymal stem cell-derived extracellular vesicles (MSC-EVs). Preserved EVs maintained structural integrity and miRNA profiles comparable to fresh EVs. In a mouse model of acute liver failure, they demonstrated equivalent therapeutic efficacy. These findings overcome storage limitations, facilitating the clinical translation of MSC-EVs as a stable treatment for liver diseases.

Fields of Study & Subjects

Extracellular vesicles in disease Organ Transplantation Techniques and Outcomes Liver physiology and pathology

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
C540–C551
Publication date
16 January 2026
Language
EN