Adamts5 deletion exacerbates inflammation and fibrosis resulting in compromised skeletal muscle regeneration
Abstract
Glycerol injury to mouse hindlimb muscles results in inefficient regeneration and fibrosis. Adamts5 is a secreted protease, which degrades extracellular matrix (ECM) proteins and has an emerging role in inflammation, fibrosis, and muscle development. In Adamts5-deficient mice, muscle degeneration, inflammation, and fibrosis were increased, and contractile function was impaired for up to 14 days after glycerol injury when compared with wild-type mice. These findings demonstrate the significant role of Adamts5 in muscle regeneration.
Fields of Study & Subjects
Muscle Physiology and Disorders
Connective Tissue Growth Factor Research
Connective tissue disorders research
Publication details
- Journal / source
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 3
- Pages
- C651–C668
- Publication date
- 28 January 2026
- Language
- EN