High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexia

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Brittany R. Counts, Andrea Bonetto, Ho Lam Chan, Ernie D. Au, Yanlin Jiang, Marion E. Couch, Denis C. Guttridge, Michael C. Ostrowski, Leonidas G. Koniaris, Teresa A. Zimmers
DOI: 10.1152/ajpcell.00545.2025
Cited by: 2
References: 40

Abstract

High-fat diet and obesity are linked to increased cancer risk, but the impact on cachexia development remains unclear. Using mouse models, this study demonstrates high-fat diet and obesity each exacerbate muscle wasting, tumor growth, and tumor and muscle IL-6 expression. Our study reveals distinct, overlapping effects with implications for cancer and cachexia interception.

Fields of Study & Subjects

Nutrition and Health in Aging Cancer Risks and Factors Muscle Physiology and Disorders

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
C727–C740
Publication date
21 February 2026
Language
EN