Distinct P2 receptors initiate intracellular signaling involved in mechanotransduction in tenocytes

American Journal of Physiology-Cell Physiology 2026 Open access

Read full text
Authors: Ryan Armstrong, Mayeesha N. Khan, Matthew William Grol
DOI: 10.1152/ajpcell.00616.2025
Cited by: 0
References: 80

Abstract

This study shows that appendicular and axial tenocytes express P2 receptors, including P2Y 2 , P2Y 6 , and P2X4. Nucleotides signal through Ca 2+ via P2Y 2 , while several P2 receptors, including P2Y 2 and P2X4, trigger transcriptome changes that influence inflammation, differentiation, and mechanical responses. Notably, this study characterizes early responses to exogenous ATP or UTP in a mammalian cell type using bulk RNA sequencing, providing valuable insights for future research.

Fields of Study & Subjects

Adenosine and Purinergic Signaling Tendon Structure and Treatment Pain Mechanisms and Treatments

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Volume
330
Issue
5
Pages
C1129–C1144
Publication date
11 March 2026
Language
EN