New insights into immunoporosis: the impact of ovariectomy on immune cell population in lymph nodes and spleen

American Journal of Physiology-Cell Physiology 2026

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Authors: Nicole Gabriele Sommer, Katharina Jandl, Begüm Okutan, Uwe Yacine Schwarze, Jan-Eike Freudenthal-Siefkes, Valentin Herber, Annelie‐Martina Weinberg
DOI: 10.1152/ajpcell.00638.2025
Cited by: 0
References: 47

Abstract

There is supporting immunological evidence in the development of osteoporosis highlighted by bone alterations. Measurements of immune cells in the blood and bone marrow do not always reflect the multifactorial, pathologic situation linked to osteoporosis. Here, we pinpoint to distinct immune cell populations in peripheral tissues, especially in lymph nodes, which are affected during the onset of osteoporosis.

Fields of Study & Subjects

Bone Metabolism and Diseases Bone health and osteoporosis research Estrogen and related hormone effects

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Volume
330
Issue
4
Pages
C1031–C1043
Publication date
4 March 2026
Language
EN