Targeting activated kidney fibroblasts via ferroptosis: a potential antifibrotic strategy

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Inga Sörensen-Zender, Rong Song, Julius Sinning, Tamar G. Kapanadze, Kai M. Schmidt-Ott, Anette Melk, Roland Schmitt
DOI: 10.1152/ajpcell.00660.2025
Cited by: 1
References: 29

Abstract

This study reveals ferroptosis, a pharmacologically inducible form of cell death, as a novel mechanism to eliminate activated fibroblasts, the main drivers of kidney fibrosis. Due to their high ferroptosis sensitivity, these cells are selectively depleted by RSL3 in vitro, in kidney tissue slice cultures, and in fibrotic kidneys in vivo. These findings highlight ferroptosis induction as a promising antifibrotic strategy in kidney disease.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Chronic Kidney Disease and Diabetes Connective Tissue Growth Factor Research

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
C619–C627
Publication date
14 January 2026
Language
EN