GPR39 activation inhibits AQP2 trafficking and alters cytoskeletal organization

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Mackenzie Kui, Jessica J. Zhang, Ibrahim Ahmed, Shishir Kumar Patel, Tara Fallah Rastegar, Hamid Rabb, Jennifer L. Pluznick
DOI: 10.1152/ajpcell.00748.2025
Cited by: 2
References: 56

Abstract

This study presents the first exploration of the cellular and molecular mechanisms underlying GPR39 activation in a physiologically relevant in vitro model of the renal collecting duct, mpkCCD cells. Our findings implicate GPR39 in the regulation of aquaporin-2 expression and trafficking, cytoskeletal organization, and cellular metabolism. In addition, RNA sequencing of GPR39-activated cells revealed transcriptomic changes related to immune signaling, stress response, and differentiation.

Fields of Study & Subjects

Ion Transport and Channel Regulation Receptor Mechanisms and Signaling Ion channel regulation and function

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
C448–C459
Publication date
7 January 2026
Language
EN