Comparison of receptor expression and cholecystokinin signaling between left and right nodose ganglia
Abstract
The left and right vagus nerves control feeding but innervate different parts of the gastrointestinal tract, suggesting differences between left and right vagal afferents and their signaling. We assessed gene expression and functional responses from left and right vagus nerves. We found the left vagus had greater expression of TRP channels, whereas the right vagus had more hormone receptors and exhibited enhanced responses to CCK. These differences advance our understanding of lateralized vagal signaling.
Fields of Study & Subjects
Vagus Nerve Stimulation Research
Ion Channels and Receptors
Gastrointestinal motility and disorders
Publication details
- Journal / source
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 4
- Pages
- C741–C751
- Publication date
- 9 February 2026
- Language
- EN