Macrophages, muscle stem cells, and repair; immunohistochemical characteristics in muscle growth impairments in children with cerebral palsy
Abstract
Muscle growth impairments seen as muscle contractures are common in children with cerebral palsy. Here we show these muscles appear to have altered macrophage populations, which are similar to joint injury-induced muscle inflammation in typically developing children. Only within contractured muscles, macrophage content, muscle stem cell abundance, capillary density and fiber characteristics are positively associated with each other, indicative of repair, similar to that seen in joint injury-induced muscle inflammation.
Fields of Study & Subjects
Cerebral Palsy and Movement Disorders
Muscle Physiology and Disorders
Spinal Cord Injury Research
Publication details
- Journal / source
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 4
- Pages
- C831–C841
- Publication date
- 4 March 2026
- Language
- EN