Activation of TMEM175 lysosomal ion channels by CysLT1 receptor antagonists

American Journal of Physiology-Cell Physiology 2026

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Authors: Kangjun Li, Vaishali Satpute Janve, Samantha D. Le, Emily Days, Joshua A. Bauer, Roman M. Lazarenko, Alican Gulsevin, Jerod S. Denton
DOI: 10.1152/ajpcell.00951.2025
Cited by: 1
References: 27

Abstract

TMEM175 regulates lysosomal voltage and pH and is genetically linked to Parkinson's disease. Our study identifies zafirlukast and related drugs as activators, defines their AKT dependency, and maps structural determinants of gating. These results open new avenues for targeting TMEM175 in neurodegenerative diseases.

Fields of Study & Subjects

Calcium signaling and nucleotide metabolism Cellular transport and secretion Neuroscience and Neuropharmacology Research

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
C715–C726
Publication date
11 February 2026
Language
EN