Moderate forced running exercise induces cartilage adaptation but exacerbates the molecular cartilage phenotype of type IX collagen knockout mice

American Journal of Physiology-Cell Physiology 2026 Open access

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Authors: Miriam Weyers, Thomas Li, Maren Dreiner, Daniela Mählich, Charlotte Lorenz, Luisa de Roy, Paola Zigrino, Lin Han, Bent Brachvogel, Frank Zaucke, Anja Niehoff
DOI: 10.1152/ajpcell.00959.2025
Cited by: 1
References: 86

Abstract

Moderate forced running exercise only slightly enhances the cartilage phenotype in aging female type IX collagen knockout mice and induces local, nondegenerative, structural and molecular adaptations in the articular cartilage ECM. Alterations in the cartilage phenotype do not depend on the age of the mice.

Fields of Study & Subjects

Osteoarthritis Treatment and Mechanisms Total Knee Arthroplasty Outcomes Collagen: Extraction and Characterization

Publication details

Journal / source
American Journal of Physiology-Cell Physiology
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
C1704–C1720
Publication date
19 May 2026
Language
EN