Correction of hypoxemia and hypoglycemia restores muscle mitochondrial respiration and remodels mitochondrial proteome in growth-restricted sheep fetuses

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Weicheng Zhao, Daniel B Chrisenberry, Mariangel Varela, Rosa I. Luna‐Ramirez, Miranda J. Anderson, Paul R. Langlais, Laura Davidson Brown, Sean W. Limesand
DOI: 10.1152/ajpendo.00073.2026
Cited by: 1
References: 33

Abstract

Using a sheep model of placental insufficiency, we showed that prenatal oxygen and glucose supplementation improved mitochondrial respiration and partially normalized mitochondrial proteomic profiles in growth-restricted fetal skeletal muscle. These findings highlight that targeted prenatal correction of hypoxemia and hypoglycemia can mitigate mitochondrial deficits associated with fetal growth restriction.

Fields of Study & Subjects

Pregnancy and preeclampsia studies Gestational Diabetes Research and Management Neonatal and fetal brain pathology

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
E774–E781
Publication date
30 April 2026
Language
EN