Twelve weeks of voluntary wheel running restores glucagon sensitivity in middle-aged mice

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Tyler J. Marx, Kassandra R. Bruner, Susma Ghimire, Thea Fletcher, Anastasiia Vasileva, Jennifer H. Stern
DOI: 10.1152/ajpendo.00244.2025
Cited by: 1
References: 37

Abstract

Few studies have examined the impact of aging on glucagon sensitivity. Here we show that glucagon sensitivity declines from young adulthood to middle age. Yet, 12 wk of voluntary wheel running, an exercise intervention without the stress of forced treadmill running or swimming, restores glucagon sensitivity in middle-aged male mice without otherwise altering glucose homeostasis.

Fields of Study & Subjects

Diabetes Treatment and Management Regulation of Appetite and Obesity Adipokines Inflammation and Metabolic Diseases

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
E257–E264
Publication date
7 January 2026
Language
EN