Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Nicole Welch, Pugazhendhi Kannan, Gangarao Davuluri, Annette Bellar, Amy Houghton Attaway, Saurabh Mishra, Jasmin Cunningham, Avinash Kumar, Ryan J. Musich, Elif G. Ertugal, Vandana Agrawal, Isaac Hsu
+7 more Terri J. Harford, Noah Weisleder, Vidula Vachharajani, Chandrasekhar R. Kothapalli, Carol A. de la Motte, Laura E. Nagy, Srinivasan Dasarathy
DOI: 10.1152/ajpendo.00283.2025
Cited by: 0

Abstract

Sarcopenia in alcohol-related liver disease (ALD) is frequent and contributes to adverse clinical outcomes with limited treatment options. Hyaluronans (glycosaminoglycan polymers) of specific fragment sizes (30-40 kDa) have anti-inflammatory and tissue-protective properties. In an array of preclinical models of ALD, we demonstrate that HA35 reverses signaling, mitochondrial oxidative function, and phenotypic perturbations associated with sarcopenia in ALD. These effects are mediated without restoring the low muscle tissue concentrations of HA in ALD.

Fields of Study & Subjects

Alcohol Consumption and Health Effects Proteoglycans and glycosaminoglycans research Liver Disease and Transplantation

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Volume
330
Issue
2
Pages
E212–E232
Publication date
7 January 2026
Language
EN