Maternal exercise during lactation remodels obesity-associated mammary metabolism and milk fatty acids, enhancing offspring lipid oxidation

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Gertrude Kyere-Davies, Kaitlyn Hill, Gregory P. Mullen, Rohan R. Varshney, Snehasis Das, Alexandrea E. Martinez, Jacob W. Farriester, Michael Kinter, Cassie M. Mitchell, Kevin R. Short, Elvira Isganaitis, David A. Fields
+1 more Michael C. Rudolph
DOI: 10.1152/ajpendo.00399.2025
Cited by: 2
References: 84

Abstract

Maternal obesity alters milk fatty acid composition, with consequences for postnatal metabolism. Maternal exercise during lactation in obese dams remodeled the mammary epithelial cell proteome, increasing medium-chain fatty acids in milk and enhancing offspring lipid oxidation.

Fields of Study & Subjects

Infant Nutrition and Health Fatty Acid Research and Health Gestational Diabetes Research and Management

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
5
Pages
E541–E561
Publication date
23 March 2026
Language
EN