Changes in weight and metabolic health during and after cessation of a time-restricted feeding plus aerobic training in Swiss mice fed a high-fat diet

American Journal of Physiology-Endocrinology and Metabolism 2026

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Authors: Renan Fudoli Lins Vieira, Susana Castelo Branco Ramos Nakandakari, Gabriel Calheiros Antunes, Ana Paula Azevêdo Macêdo, Robson Damasceno de Lima, Thaiane da Silva Rios, Natália Tobar, Vítor Rosetto Muñoz, Rafael Calais Gaspar, A. S. R. da Silva, Cintra, Dennys Esper, 1976-, Eduardo Rochete Ropelle
+2 more Amandine Chaix, José Rodrigo Pauli
DOI: 10.1152/ajpendo.00432.2025
Cited by: 1
References: 42

Abstract

This study demonstrates that combining time-restricted feeding with aerobic training improves weight and metabolic health in Swiss mice fed a high-fat diet. Importantly, we show that most metabolic benefits are lost after intervention cessation. However, insulin sensitivity and aspects of hepatic lipid metabolism are partially maintained after cessation of the intervention. These findings provide new insight into the durability of metabolic improvements induced by lifestyle interventions and highlight the potential of combined dietary and exercise strategies to counteract diet-induced obesity and metabolic dysfunction.

Fields of Study & Subjects

Dietary Effects on Health Circadian rhythm and melatonin Adipose Tissue and Metabolism

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
E431–E441
Publication date
11 February 2026
Language
EN