Ketone monoester ingestion improves endothelial function during hyperglycemia in females with polycystic ovary syndrome

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Danielle E. Berbrier, Will Huckins, Shannon I. Delage, Emily K Van Berkel, Sarkis J. Hannaian, Raychel Myara, Oluwakanyisola N. Okafor, Ta Heh Chung, T. Tulandi, Shauna L. Reinblatt, Rachel N. Lord, Tyler A. Churchward-Venne
+1 more Charlotte Willemina Usselman
DOI: 10.1152/ajpendo.00453.2025
Cited by: 1
References: 116

Abstract

To the best of our knowledge, this is the first study to demonstrate that nonobese females with polycystic ovary syndrome (PCOS) exhibit prolonged impairments in endothelial function following glucose intake, indicating sustained hyperglycemia-driven vascular dysfunction. Notably, acute ketone monoester (KME) supplementation improved both glycemic control and endothelial function, highlighting KME as a promising nonpharmacological strategy to mitigate early cardiometabolic risk in this vulnerable population.

Fields of Study & Subjects

Diet and metabolism studies Cardiovascular Function and Risk Factors Ovarian function and disorders

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
E196–E211
Publication date
7 January 2026
Language
EN