Exercise attenuates polycystic ovary syndrome development via improved mitochondrial proteostasis

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Chaeyoung Shin, Liwei Chen, Md Nazmul Hossain, Xinrui Li, Sharmeen Islam, Zhongyun Kou, Qiaorong Cui, J Arnzen de Avila, Zhu Mj, ‬Min Du
DOI: 10.1152/ajpendo.00457.2025
Cited by: 2
References: 51

Abstract

This study identifies mitochondrial proteostasis as an important molecular mechanism underlying the beneficial effects of aerobic exercise in improving polycystic ovary syndrome (PCOS). Exercise attenuated PCOS development and pathology through normalizing steroidogenic enzyme degradation via LONP1 upregulation, suppressing ovarian inflammation and fibrosis, and activating mitochondrial biogenesis pathways. Although the beneficial effects of exercise on PCOS have been well recognized, this study reveals the mitochondrial proteostasis pathway underlying these preventive effects.

Fields of Study & Subjects

Ovarian function and disorders Reproductive Biology and Fertility Ovarian cancer diagnosis and treatment

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
E390–E400
Publication date
16 February 2026
Language
EN