Cardiometabolic and metabolic profiles in irritable bowel syndrome associated with type 2 diabetes

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Franziska Schmelter, Lotta Nowak, Paul Beier, Vivian Tetzlaff-Lelleck, Anna Kordowski, Bandik Föh, Oliver Witt, Torsten Schröder, Ulrich L. Günther, Yves Laumonnier, Benjamin AH Jensen, Stephan C. Bischoff
+2 more Stefanie Derer, Christian Sina
DOI: 10.1152/ajpendo.00489.2025
Cited by: 2
References: 39

Abstract

We identified a distinct cardiometabolic risk profile in patients with IBS, characterized by elevated BMI, triglycerides, HbA1c, and reduced HDL-C levels. Metabolic phenotyping reveals a pattern in patients with IBS comparable with T2D profiles, including altered amino acid, glucose, and lipid metabolism.

Fields of Study & Subjects

Gastrointestinal motility and disorders Diet and metabolism studies Gut microbiota and health

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
E422–E430
Publication date
18 February 2026
Language
EN