Impact of AKR1C2 and AKR1C3 single-nucleotide polymorphism rs28571848 in adipose tissues of individuals with severe obesity

American Journal of Physiology-Endocrinology and Metabolism 2026 Open access

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Authors: Giada Ostinelli, Alan Ramalho, Marie‐Frédérique Gauthier, François Julien, Laurent D. Biertho, Marie‐Claude Vohl, André Tchernof
DOI: 10.1152/ajpendo.00512.2024
Cited by: 0
References: 49

Abstract

rs28571858 has a minor allele frequency of 18.7% in a cohort of 2,776 residents of Quebec, Canada. rs28571858 is associated with adipose tissue AKR1C3 expression and activity in women. Minor allele homozygote carriers have increased total cholesterol, LDL-cholesterol, and indices of insulin resistance.

Fields of Study & Subjects

Aldose Reductase and Taurine Peroxisome Proliferator-Activated Receptors Adipose Tissue and Metabolism

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Volume
330
Issue
3
Pages
E276–E286
Publication date
8 January 2026
Language
EN