Gut microbiota transplantation from young adult mice fails to restore low bone and muscle mass in old mice

American Journal of Physiology-Endocrinology and Metabolism 2026

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Authors: Lina Lawenius, Daniel A. Hägg, Karin Horkeby, Karin H. Nilsson, Jianyao Wu, Louise Grahnemo, Claes Ohlsson, Klara Sjogren
DOI: 10.1152/ajpendo.00522.2025
Cited by: 1
References: 58

Abstract

Aging is associated with reduced lean and bone mass and changes in gut microbiota (GM). We tested whether transplanting young adult GM could reverse these age-related conditions in old mice. GM transplantation resulted in distinct GM compositions between mice receiving young adult versus old donor GM, but neither lean nor bone mass was restored in old mice. These findings suggest that GM from young adult mice cannot restore musculoskeletal deficits in aging.

Fields of Study & Subjects

Gut microbiota and health Clostridium difficile and Clostridium perfringens research Dietary Effects on Health

Publication details

Journal / source
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
E461–E470
Publication date
4 March 2026
Language
EN