Acute interleukin-1β antagonism decreases systemic inflammation, increases GLP-1 release, and modulates insulin secretion in individuals with prediabetes
Abstract
Acute IL-1 blockade with anakinra markedly reduced CRP and leukocyte counts within 12 h, demonstrating rapid anti-inflammatory efficacy. Anakinra induced a trend toward earlier insulin secretion and significantly increased postprandial IL-6 and GLP-1 levels. The study demonstrates that even short-term IL-1 blockade can modulate both immune and incretin responses in prediabetes. Early IL-1β antagonism may represent a preventive, anti-inflammatory approach to preserve GLP-1 secretion and β-cell function in individuals with prediabetes.
Fields of Study & Subjects
Adipokines
Inflammation
and Metabolic Diseases
Sodium Intake and Health
Regulation of Appetite and Obesity
Publication details
- Journal / source
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 4
- Pages
- E500–E509
- Publication date
- 4 March 2026
- Language
- EN