Association between interlobular pancreatic adipose tissue and low glucose-induced insulin secretion by β-cells
Abstract
Adipose tissue infiltration in the pancreas and its potential implication in the development or maintenance of diabetes has been and is still intensively investigated. In this short communication, we showed negative association between pancreatic fat infiltration and glucose-stimulated insulin secretion (GSIS), specifically in T2D. In addition, interlobular adipocyte size correlated positively with body mass index, age, and HbA1c, and negatively with GSIS. This suggests that adipocyte phenotype, rather than fat quantity alone, may influence β-cell function.
Fields of Study & Subjects
Pancreatic function and diabetes
Pancreatitis Pathology and Treatment
Adipokines
Inflammation
and Metabolic Diseases
Publication details
- Journal / source
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Volume
- 331
- Issue
- 1
- Pages
- G102–G106
- Publication date
- 12 June 2026
- Language
- EN