Inhibitory effects of somatostatin on glucagon-like peptide-1-mediated acceleration of peristalsis in the rat proximal colon
Abstract
Somatostatin inhibited the prokinetic action of glucagon-like peptide-1 (GLP-1), short-chain fatty acids, and lipopolysaccharide. The inhibitory effect of somatostatin was mediated by the activation of somatostatin receptor subtype 5 that was expressed on L cells. Sources of somatostatin were D cells and intrinsic primary afferent neurons, both of which expressed GLP-1 receptors. Thus, colonic peristalsis may well be regulated by the functional interaction between excitatory GLP-1 and inhibitory somatostatin.
Fields of Study & Subjects
Gastrointestinal motility and disorders
Neuropeptides and Animal Physiology
Diabetes Treatment and Management
Publication details
- Journal / source
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Volume
- 330
- Issue
- 3
- Pages
- G256–G269
- Publication date
- 27 January 2026
- Language
- EN