Loss of histone deacetylase 4 in hepatocytes perturbs lipid metabolism and insulin signaling in mice with diet-induced obesity

American Journal of Physiology-Gastrointestinal and Liver Physiology 2026

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Authors: Hyungryun Jang, Minkyung Bae, Yoojin Lee, Hyunju Kang, Mi-Bo Kim, Siqi Hu, Olivia Corvino, Jaeeun Lee, Jaeeun Lee, Hayoung Woo, Victoria Kostour, William Odell
+4 more A. Kim, Young‐Ki Park, Ji‐Young Lee, Ji‐Young Lee
DOI: 10.1152/ajpgi.00225.2025
Cited by: 0
References: 45

Abstract

We examined the role of hepatocyte histone deacetylase 4 (HDAC4) in the development of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) using Hdac4-deficient mice with hepatocyte-specific deletion. We found that deleting Hdac4 in hepatocytes worsens hepatic steatosis and disrupts insulin signaling in the liver. In addition, this deletion caused inflammation and fibrosis in the white adipose tissue of obese mice, highlighting the role of HDAC4 in the liver-adipose axis.

Fields of Study & Subjects

Histone Deacetylase Inhibitors Research Liver Disease Diagnosis and Treatment Adipokines Inflammation and Metabolic Diseases

Publication details

Journal / source
American Journal of Physiology-Gastrointestinal and Liver Physiology
Volume
330
Issue
2
Pages
G195–G205
Publication date
9 January 2026
Language
EN