Role of serine/threonine phosphatases 1 and 2A in pancreatic acinar fluid and electrolyte secretion
Abstract
The roles of the serine/threonine phosphatase 1/2A in mediating fluid/electrolyte secretion by pancreatic acinar cells remains unclear. This study demonstrates that PP1/PP2A are activated vasoactive intestinal peptide (VIP)/secretin in pancreatic acini. VIP/secretin both activate PP1/PP2A but differed for their ability to activate exchange protein directly activated by cAMP (EPAC) and protein kinase A (PKA). VIP/secretin require PAK4, not PAK2, activation to stimulate PP2A, not PP1; however, PP1/PP2A activation stimulate sodium-potassium adenosine triphosphatase (Na + -K + -ATPase) activity. This study shows that PP1/PP2A play important roles in VIP-secretin-stimulated pancreatic acinar fluid/electrolyte secretion.
Fields of Study & Subjects
Protein Kinase Regulation and GTPase Signaling
Pancreatic function and diabetes
Cellular transport and secretion
Publication details
- Journal / source
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Volume
- 330
- Issue
- 2
- Pages
- G225–G241
- Publication date
- 12 January 2026
- Language
- EN