Sex-specific differences in liver DNA methylation patterns and epigenetic aging in mice

American Journal of Physiology-Gastrointestinal and Liver Physiology 2026 Open access

Read full text
Authors: Shant Apelian, Ramanaiah Mamillapalli, Abdullah Ucar, Nimisha Gawde, Hugh Stott Taylor
DOI: 10.1152/ajpgi.00322.2025
Cited by: 1
References: 47

Abstract

Males and females are known to age differently and develop certain diseases at different rates. Here, we examined the livers of aged male and female mice to see if they show different DNA methylation patterns. We found that aged male and female mice had distinct DNA methylation patterns at specific genes. Interestingly, most of these methylation differences were not present in younger mice, suggesting that sex differences in the genome may change with age.

Fields of Study & Subjects

Epigenetics and DNA Methylation Sex and Gender in Healthcare Pharmacogenetics and Drug Metabolism

Publication details

Journal / source
American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
G361–G367
Publication date
16 February 2026
Language
EN