Role of interstitial cells of Cajal in regulating tone and responses to enteric motor neurons in the murine pyloric sphincter

American Journal of Physiology-Gastrointestinal and Liver Physiology 2026 Open access

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Authors: Ji Yeon Lee, Sang Don Koh, Sal A. Baker, Kenton M. Sanders
DOI: 10.1152/ajpgi.00350.2025
Cited by: 1
References: 48

Abstract

The pyloric sphincter is an electrical insulator between the stomach and small intestine, isolating and maintaining the unique motility patterns of these organs. Using Ca 2+ imaging techniques, this study demonstrates why slow waves do not propagate between organs and how interstitial cells of Cajal serve to regulate pyloric tone and responses to enteric motor neurons.

Fields of Study & Subjects

Gastrointestinal motility and disorders Neuroscience of respiration and sleep Vagus Nerve Stimulation Research

Publication details

Journal / source
American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
G330–G340
Publication date
22 January 2026
Language
EN