MrgprC11 expression and function in vagal afferent nerves in the esophagus

American Journal of Physiology-Gastrointestinal and Liver Physiology 2026 Open access

Read full text
Authors: Xiaoyun Yu, Yongming Huang, Mayur Jayanta Patil, Yanyan Xing, F. Ru, Ryo Kawamoto, Liang Han, Bradley J. Undem, Xinzhong Dong, Shaoyong Yu
DOI: 10.1152/ajpgi.00363.2025
Cited by: 0
References: 30

Abstract

MrgprC11 belongs to the recently discovered Mrgpr family and plays a crucial role in somatic sensory transduction. Its functional expression in visceral esophageal afferent nerves has yet to be defined. The present study demonstrated a functional role of MrgprC11 in mediating activation and sensitization of esophageal vagal afferent C-fibers, revealing a novel nociceptive sensory transduction mechanism in the esophagus.

Fields of Study & Subjects

Ion Channels and Receptors Pain Mechanisms and Treatments Gastrointestinal motility and disorders

Publication details

Journal / source
American Journal of Physiology-Gastrointestinal and Liver Physiology
Volume
330
Issue
3
Pages
G341–G348
Publication date
11 February 2026
Language
EN