Fibroblast-specific Gpx4 deletion exacerbates IBD via lipid peroxidation

American Journal of Physiology-Gastrointestinal and Liver Physiology 2026 Open access

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Authors: Yuezhong Zhang, Yinzhi Ying, Wesley Huang, Zoé Rosenfeld, Marwa O. El-Derany, Zheng Hong Lee, Cristina Garfia Castillo, Tae Gyu Oh, Joel K. Greenson, Yatrik Madhukar Shah
DOI: 10.1152/ajpgi.00387.2025
Cited by: 1
References: 34

Abstract

Fibroblast-specific GPX4 deletion promotes IBD progression. Lipid peroxidation could be a potential therapeutic target of IBD.

Fields of Study & Subjects

Ferroptosis and cancer prognosis Immune cells in cancer Bone and Dental Protein Studies

Publication details

Journal / source
American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher
American Physiological Society
Volume
330
Issue
5
Pages
G591–G600
Publication date
9 April 2026
Language
EN