Bolus pressure and bolus mismatch in patients with dysphagia and preserved esophageal peristalsis
Abstract
This study introduces a novel impedance-based method to analyze the bolus domain of esophageal peristalsis, emphasizing bolus pressure and bolus mismatch. Patients with functional dysphagia and EGJOO demonstrated impaired esophageal distension, reduced wall compliance, and frequent pseudo-bolus pressures from transient luminal collapse during peristalsis. These findings suggest that dysphagia may result from dynamic obstruction due to esophageal collapse during peristalsis rather than fixed outflow obstruction, highlighting bolus domain mechanics as a complementary diagnostic tool.
Fields of Study & Subjects
Gastroesophageal reflux and treatments
Esophageal and GI Pathology
Dysphagia Assessment and Management
Publication details
- Journal / source
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 3
- Pages
- G293–G301
- Publication date
- 31 January 2026
- Language
- EN