New approach methodologies in Crohn’s disease link molecular disease subtypes to clinical outcomes

American Journal of Physiology-Gastrointestinal and Liver Physiology 2026 Open access

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Authors: Harrison M. Penrose, Saptarshi Sinha, Courtney Tindle, Kameron M. Zablan, Helen N. Le, Jennifer Neill, Pradipta Ghosh, Brigid Sweeney Boland
DOI: 10.1152/ajpgi.00393.2025
Cited by: 1
References: 44

Abstract

In this prospective study, Penrose et al. evaluate a living biobank of genotyped and phenotyped patient-derived organoids (PDOs) as predictive tools in Crohn's disease, demonstrating their ability to faithfully capture past, present, and future disease behavior. By positioning PDOs as new approach methodologies (NAMs), this work extends PDO-informed precision medicine beyond oncology and into complex inflammatory disorders, translating molecular diversity into actionable clinical insights.

Fields of Study & Subjects

Inflammatory Bowel Disease Single-cell and spatial transcriptomics Cancer Cells and Metastasis

Publication details

Journal / source
American Journal of Physiology-Gastrointestinal and Liver Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
G322–G329
Publication date
10 February 2026
Language
EN