SGK1 signaling: an important modulator of CFTR function and early immune response in mouse intestine
Abstract
Glucocorticoids rapidly boost intestinal CFTR expression, function, and trafficking through SGK1 and link stress signaling to epithelial secretion and immune control. Deleting Sgk1 blocked glucocorticoid-driven CFTR activation and altered early immune cell recruitment, uncovering SGK1 as a critical regulator of intestinal adaptation to acute stress.
Fields of Study & Subjects
Ion Transport and Channel Regulation
Gastrointestinal motility and disorders
Drug Transport and Resistance Mechanisms
Publication details
- Journal / source
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 4
- Pages
- G487–G494
- Publication date
- 18 February 2026
- Language
- EN