Esophageal mucosal mast cell density and degranulation are increased in gastroesophageal reflux disease
Abstract
This is the first study to characterize mast cell localization and degranulation in subjects with pH-phenotyped FH, NERD, and ERD compared with healthy controls, showing elevated mast cell numbers in ERD, with increased degranulation in all patient groups (FH, NERD, and ERD). These findings suggest that mast cell activation may contribute to mucosal inflammation and symptom generation in GERD, particularly FH.
Fields of Study & Subjects
Gastroesophageal reflux and treatments
Gastrointestinal motility and disorders
Eosinophilic Esophagitis
Publication details
- Journal / source
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 4
- Pages
- G414–G423
- Publication date
- 10 February 2026
- Language
- EN