TNF-α alters dedifferentiation of enterochromaffin cells, redirecting toward neuroendocrine tumors
Abstract
Small intestinal neuroendocrine tumors are of putative enterochromaffin (EC) cell origin and are the most common malignancy in the small intestine. However, the tumorigenesis of these specified tumor types remains poorly understood. The present organoid studies show that the addition of TNF-α to the microenvironment maintains the specificity of EC cells during their transformation to neuroendocrine tumors while blocking their dedifferentiation to ISC-derived adenomas.
Fields of Study & Subjects
Neuroendocrine Tumor Research Advances
Gastrointestinal Tumor Research and Treatment
Helicobacter pylori-related gastroenterology studies
Publication details
- Journal / source
- American Journal of Physiology-Gastrointestinal and Liver Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 5
- Pages
- G581–G590
- Publication date
- 28 March 2026
- Language
- EN