Inflammatory pain alters colorectal motility via spinal oxytocinergic pathways

American Journal of Physiology-Gastrointestinal and Liver Physiology 2026 Open access

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Authors: Tomoya Sawamura, Ayuna Mori, Natsufu Yuki, Kazuya Takashima, Yuuki Horii, Mitsuhiro Yoshimura, Yoichi Ueta, Takahiko Shiina, Yasutake Shimizu
DOI: 10.1152/ajpgi.00427.2025
Cited by: 0
References: 45

Abstract

This study focused on the remodeling of the neural pathways regulating colorectal motility and examined whether peripheral inflammation outside the gastrointestinal tract affects this process. In rats administered a complete Freund's adjuvant into their hind paw, colorectal motility responses induced by intracolonic administration of capsaicin were suppressed. This suppression involved oxytocinergic and GABAergic transmission in the spinal cord. These results demonstrate that inflammatory pain in the hind paw induces remodeling of the neural pathways regulating colorectal motility.

Fields of Study & Subjects

Gastrointestinal motility and disorders Pain Mechanisms and Treatments Neuropeptides and Animal Physiology

Publication details

Journal / source
American Journal of Physiology-Gastrointestinal and Liver Physiology
Volume
330
Issue
2
Pages
G214–G224
Publication date
17 January 2026
Language
EN