Myeloid-derived immunosuppressive PD-1/PD-L1 signaling is essential to maintain adult heart homeostasis

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Angelica Toro Cora, Arvind Singh Bhati, Amdadul Huque, Imran Ansari, Baldeep Singh, Rohan Sethi, Daniel Y. Li, Qinkun Zhang, Alok Pant, Sindhu Priya Devarashetty, Hind Lal, Tousif Sultan
DOI: 10.1152/ajpheart.00017.2026
Cited by: 1
References: 46

Abstract

Immune checkpoint inhibitor-associated myocarditis is incompletely understood beyond T cell-driven mechanisms. This study identifies myeloid-specific PD-L1 as a critical regulator of cardiac immune homeostasis. Loss of myeloid PD-L1 triggers early myocardial inflammation, immune cell infiltration, FB activation, and subsequent cardiac dysfunction. These findings uncover a previously unrecognized myeloid checkpoint pathway contributing to immune-mediated cardiotoxicity and highlight myeloid PD-L1 as a potential therapeutic target.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Cardiac Fibrosis and Remodeling Immune cells in cancer

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
1
Pages
H276–H292
Publication date
1 June 2026
Language
EN